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Pharmacology: Pharmacodynamics: Metformin is a biguanide hypoglycemic agent lowering both basal and postprandial plasma glucose. It does not stimulate insulin secretion and as a result does not produce hypoglycemia.
Pharmacokinetics: Metformin Hydrochloride (Gludin) is slowly and incompletely absorbed from the gastrointestinal tract. A single 500 mg dose is reported to have a bioavailability of 50-60% (may be reduced in the presence of food). Plasma protein binding is negligible. It is excreted as unchanged drug in the urine. Plasma elimination half-life is reported to range about 2 to 6 hours after oral administration.
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