Dosage of Metformin Hydrochloride (Gludin) may be lowered in patients receiving Metformin Hydrochloride and Cimetidine to reduce the risk of Lactic Acidosis. Diuretics may increase the risk of Lactic Acidosis due to their potential to decrease renal function. Avoid consumption of alcohol and alcohol-containing medications, as it may cause increase risk of Lactic Acidosis.