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An overdose of sulfonylurea may cause hypoglycemia. Moderate symptoms of hypoglycemia, without any loss of consciousness or neurological signs, must be corrected by carbohydrate intake, dose adjustment, and/or diet change. Strict monitoring should be continued until the doctor is sure that the patient is out of danger. If hypoglycemic coma is diagnosed or suspected, the patient should be given a rapid I.V. injection of 50 mL of concentrated glucose solution (20 to 30%). This should be followed by continuous infusion of a more dilute glucose solution (10%) at a rate that will maintain blood glucose levels above 1 g/L. Dialysis is of no benefit to patients due to the strong binding of Gliclazide to proteins.
The administration of an excessive dose results in hypoglycemia (refer to Precautions), which should be treated immediately by the administration of sugar.
If the patient is unconscious, immediately inform a doctor and call the emergency service.
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