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With Medicine: The hypoglycemic effects of Gliclazide may be increased by Aspirin, NSAIDs, Phenylbutazone, Clofibrate, Sulfonamide, Cimetidine, Imidazole antifungal agents, and Monoamine Oxidase Inhibitors. The hypoglycemic effect of Gliclazide may sometimes be reduced by Rifampin, Barbiturates, Phenytoin, Thiazide diuretics, Diazoxide, Glucocorticoids, Estrogens, Sympathomimetic drugs, and occasionally alcohol.
With food: There are no established drug-food interactions.
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