Geotrixx Special Precautions

Before therapy with ceftriaxone is instituted, careful inquiry should be made to determine whether the patient has had previous hypersensitivity reactions to cephalosporins, penicillins or other drugs. Antibiotics should be administered with caution to any patient who has demonstrated some form of allergy, particularly to drugs. Serious acute hypersensitivity reactions may require the use of subcutaneous epinephrine and other emergency measures.
Patients with renal failure and hepatic dysfunction normally require no adjustment in dosage when usual doses of ceftriaxone are administered but concentrations of drug in the serum should be monitored periodically.
There have been reports of sonographic abnormalities in the gallbladder of patients treated with ceftriaxone, some of these patients also had symptoms of gallbladder disease. These abnormalities appear on sonography as an echo without acoustical shadowing suggesting sludge or as an echo with acoustical shadowing which may be misinterpreted as gallstones. The chemical nature of the sonographically detected material has been determined to be predominantly a ceftriaxone-calcium salt. The condition appears to be transient and reversible upon discontinuation of ceftriaxone and institution of conservative management. Therefore, ceftriaxone should be discontinued in patients who develop signs and symptoms suggestive of gallbladder disease and/or the sonographic findings described previously.
Interference with Laboratory Tests: A positive Coombs' test may be seen during treatment with cephalosporins. A false-positive reaction to glucose may occur with reducing substances but not with the use of specific glucose oxidase methods.
A false-positive galactosemia test may occur like other antibiotics.