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There are limited data on the overdose with oral Fosfomycin.
Signs and symptoms: Cases of hypotonia, somnolence, electrolyte disturbances, thrombocytopaenia, and hypoprothrombinaemia have been reported after parenteral administration of fosfomycin.
Treatment: In the event of overdose, the patient must be monitored (particularly for plasma/serum electrolyte levels), and treatment should be symptomatic and supportive. Rehydration is recommended to promote urinary elimination of the active substance. Fosfomycin is effectively cleared from the body by haemodialysis with a mean elimination half-life of approximately 4 hours.
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