Fosfa Caution For Usage

Handling and Disposal: Preparation of Ifosfamide for Injection, USP should be done in a vertical laminar flow hood (Biological Safety Cabinet-Class II). Personnel preparing Ifosfamide should wear PVC gloves, safety glasses, disposable gowns and masks. All needles, syringes, vials and other materials which have come in contact with Ifosfamide should be segregated and incinerated at 1000°C or more. Proper precautions should be taken in packaging these materials for transport. Personnel regularly involved in the preparation and handling of Ifosfamide should have bi-annual blood examinations. Procedures for proper handling and disposal of anticancer drugs should be considered. Skin reactions associated with accidental exposure to may occur. If solution contacts the skin or mucosa, immediately wash the skin thoroughly with soap and water or rinse the mucosa with copious amounts of water. Several guidelines on this subject have been published; however there is no general agreement that all of the procedures recommended in the guidelines are necessary or appropriate.
Direction for Reconstitution: Injections are prepared for parenteral use by adding Sterile Water for Injection USP or Sterile Bacteriostatic Water for Injection USP (benzyl alcohol or paraben preservative) to the vial and shaking to dissolve. If dissolution does not take place immediately, allow to stand for few minutes and shake again. It is advisable to use the preparation immediately after reconstitution. Use the quantity of diluent shown as follows to constitute the product: (See table.)

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Solutions of Ifosfamide may be diluted further to achieve concentrations of 0.6 to 20 mg/mL in either 5% Dextrose Injection USP, 0.9% Sodium Chloride Injection USP, Lactated Ringer's Injection USP and Sterile Water for Injection USP. For intravenous infusions lasting approximately 30 minutes, dilution with 250 mL Ringer's solution or 5% dextrose solution or 0.9% sodium chloride solution is appropriate; however for intravenous infusions lasting from 1-2 hours, dilution with 500 mL Ringer's solution or 5% dextrose solution or 0.9% sodium chloride solution has been found to be appropriate. The use of large volume parenteral glass bottles for infusion is also acceptable. Reconstituted or constituted and further diluted solutions of should be refrigerated and used within 24 hours. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. "Single dose. Discard any remaining portion."