Sign Out
Effects on the heart: Severe myocardial depression, with heart failure and ventricular arrhythmias, has been reported in patients given high-dose ifosfamide. Symptoms were reversible with appropriate treatment in most cases.
Effects on the kidneys: In addition to its effects on the bladder ifosfamide may be associated with serious nephrotoxicity. Both proximal and distal tubular damage and to a lesser extent glomerular effects are seen.
Effects on the nervous system: Use of ifosfamide (with mesna for urothelial protection) may be associated with the development of severe encephalopathy, with EEG abnormalities, disorientation, hallucinations, catatonia, and coma; occasionally CNS depression has led to circulatory collapse and death.
View ADR Reporting Link
Continue with Google