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Each vial contains: Ifosfamide 1 g.
Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. Ifosfamide is chemically 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine2-oxide. The molecular formula is C7H15Cl2N2O2P and its molecular weight is 261.1.
Ifosfamide is a white crystalline powder that is soluble in water; has a melting point of 48-51°C. The pH of a 10% solution of Ifosfamide is between 4.5-7.0. Ifosfamide begins to sinter below the melting point and therefore has to be stored at a controlled temperature, that is as low as possible. It is also advisable to control humidity as Ifosfamide highly hygroscopic. Although Ifosfamide dissolves to an extent of about 10% by weight in water, it only has limited stability in aqueous solution. Ifosfamide for injection is presented as single-dose 1, 2 and 3 gram vials for reconstitution and administration as intravenous infusion only.
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