Duomax Overdosage

Rifampicin: Nausea, vomiting and increasing lethargy appears within a short time after ingestion, unconsciousness may occur when there is severe hepatic disease. Brownish-red or orange discoloration of the skin, urine, sweat, saliva, tears and feces will occur and its intensity is proportional to the amout ingested. Liver enlargement, possibly with tenderness, may develop within a few hours after severe overdosage, jaundice may develop rapidly. Other physical findings remain essentially normal. Bilirubin levels may increase rapidly with severe overdosage. The treatment is supportive.
Isoniazid: Nausea, vomiting, dizziness, slurring of speech, blurring of vision and visual hallucinations are early manifestations of overdosage. Respiratory distress and central nervous system depression progressing to coma with or without seizures, may occur with marked overdosage. Severe metabolic acidosis, acetonuria and hyperglycemia are typical laboratory findings. Treatment consists of gastric lavage following intubation and the control of convulsions by diazepam IV. Large doses of pyridoxine may have to be given IV. Metabolic acidosis can be corrected by sodium bicarbonate.