Rifampicin: Being an inducer of cytochrome P-450 enzymes, rifampicin may accelerate elimination of certain drugs using this metabolic pathway. These include phenytoin, antiarrhythmics (disopyramide, mexiletine, quinidine), anticoagulants, antifungals (fluconazole, itraconazole, ketoconazole), barbiturates, β-blockers, calcium-channel blockers (diltiazem, nifedipine, verapamil), chloramphenicol, ciprofloxacin, corticosteroids, cyclosporine, cardiac glycosides, oral contraceptives, clofibrate, dapsone, diazepam, haloperidol, oral hypoglycemic agents, narcotic analgesics, progestins and theophylline. It may be necessary to adjust the dosage of these drugs if they are given concurrently with Duomax.
Isoniazid: Isoniazid inhibits the metabolism of anticonvulsants, benzodiazepines, haloperidol, ketoconazole, theophylline and warfarin. It may be necessary to adjust the dosage of these drugs if they are given concurrently with Duomax.
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