Dolan FP/Dolan FP Forte Drug Interactions

Aspirin: Ibuprofen may interfere with the anti-platelet activity of aspirin, thus limiting aspirin's cardioprotective effect.
Other NSAIDs: Phenylbutazone, indomethacin, salicylates (e.g., aspirin), and other NSAIDs (e.g., mefenamic acid, naproxen, diclofenac, ketoprofen), including cyclooxygenase (COX)-2 inhibitors (e.g., celecoxib, etoricoxib), increase the risk of stomach and intestinal bleeding in patients receiving ibuprofen.
Aminoglycosides: NSAIDs, such as ibuprofen, increase aminoglycoside toxicity by decreasing the excretion of aminoglycoside antibiotics (e.g., amikacin, gentamicin, neomycin, tobramycin).
Antacids: The plasma levels of ibuprofen may be increased when taken together with antacids such as magnesium hydroxide.
Antihypertensives and Diuretics: NSAIDS may reduce the effect of these drugs (e.g., captopril, enalapril, losartan, telmisartan); diuretics (e.g., furosemide) may also cause acute reduction in kidney function of NSAIDs.
Blood Thinning Medicines (Anticoagulants): When taken with blood thinning (anticoagulant) medicines (e.g., warfarin, dicumarol) or together with thrombolytic agents (e.g., streptokinase), ibuprofen may cause stomach and intestinal bleeding.
Cardiac Glycosides: NSAIDs may worsen heart failure, reduce kidney function and increase blood levels of these medicines (e.g., digoxin).
Cholestyramine: May reduce the absorption of ibuprofen.
Ciclosporin and Tacrolimus: Increased risk of kidney damage.
Corticosteroids, Selective Serotonin-Reuptake Inhibitors (SSRIs), and Anti-platelet Agents: May increase the risk of stomach bleeding with ibuprofen.
Ginkgo Biloba: May enhance the risk of bleeding when given with ibuprofen.
Lithium and Methotrexate: Ibuprofen increases the amount of lithium and methotrexate in the blood, thus increasing the risk of toxicity.
Medicines Affecting Liver Enzymes: Medicines which hinder the enzymes responsible for the metabolism of ibuprofen may alter its safety and efficacy.
Medicines that Lower Blood Sugar (for Diabetes): Ibuprofen may increase plasma levels of medicines used to treat diabetes (sulfonylureas such as gliclazide, glipizide, glimepiride) and insulin by inhibiting their metabolism.
Probenecid: May reduce the metabolism and excretion of ibuprofen, thus increasing the risk of ibuprofen toxicity.
Quinolone Antibiotics: A possible increased risk of convulsions may occur with ibuprofen.
Zidovudine: An increased risk of blood problems such as bleeding into a joint (hemarthrosis) and bruising (hematoma) may result when given with ibuprofen.
Tell the doctor if the patient is taking other medicines, including vitamins, supplements, and herbal medicines.