Thrombotic thrombocytopenic purpura (TTP) has been reported rarely following use of clopidogrel, sometimes after a short exposure (<2 weeks). TPP is a serious condition requiring prompt treatment. It is characterized by thrombocytopenia, microangiopathic hemolytic anemia (schistocytes [fragmented RBCs] seen on peripheral smear), neurological findings, renal dysfunction, and fever.