Deplatt Dosage/Direction for Use

Acute Coronary Syndrome: Clopidogrel bisulfate tablets can be administered with or without food.
For patients with non-ST-elevation ACS (UA/NSTEMI), initiate clopidogrel bisulfate tablets with a single 300 mg oral loading dose and then continue at 75 mg once daily. Initiate aspirin (75 to 325 mg once daily) and continue in combination with clopidogrel bisulfate.
For patients with STEMI, the recommended dose of clopidogrel bisulfate tablets is 75 mg once daily orally, administered in combination with aspirin (75 to 325 mg once daily), with or without thrombolytics. Clopidogrel bisulfate tablets may be initiated with or without a loading dose.
Recent MI, Recent Stroke, or Established Peripheral Arterial Disease: The recommended daily dose of clopidogrel bisulfate tablets is 75 mg once daily orally, with or without food.
CYP2C19 Poor Metabolizers: CYP2C19 poor metabolizer status is associated with diminished antiplatelet response to clopidogrel.
Although a higher dose regimen in poor metabolizers increases antiplatelet response, an appropriate dose regimen for this patient population has not been established.
Use with Proton Pump Inhibitors (PPI): Avoid using omeprazole or esomeprazole with clopidogrel bisulfate tablets. Omeprazole and esomeprazole significantly reduce the antiplatelet activity of clopidogrel bisulfate tablets. When concomitant administration of a PPI is required, consider using another acid-reducing agent with minimal or no CYP2C19 inhibitory effect on the formation of clopidogrel active metabolite.