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Deplatt

Deplatt

clopidogrel

Manufacturer:

Torrent

Distributor:

Torrent
Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing
Concise Prescribing Info
Contents
Clopidogrel bisulfate
Indications/Uses
Reduction of thrombotic events in recent MI, recent stroke or established peripheral arterial disease, acute coronary syndromes.
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Dosage/Direction for Use
Recent MI, stroke or established peripheral arterial disease 75 mg once daily. Non-ST-elevation acute coronary syndrome (UA/NSTEMI) Initially 300 mg as a single loading dose, then continued at 75 mg once daily. Initiate aspirin 75-325 mg once daily in combination w/ clopidogrel bisulfate. STEMI 75 mg once daily administered in combination w/ aspirin 75-325 mg once daily w/ or w/o thrombolytic. Clopidogrel bisulfate tab may be initiated w/ or w/o loading dose.
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Overdosage
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Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Active pathological bleeding eg, peptic ulcer or intracranial hemorrhage.
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Special Precautions
Increased risk of bleeding. Reports of hypersensitivity including rash, angioedema or hematologic reaction; cross-reactivity among thienopyridines; TTP. Discontinue treatment 5 days prior to surgery if antiplatelet effect is not desired. Premature discontinuation may increase risk of CV events. Metabolism to active metabolite can be impaired by generic variations in CYP2C19 & by concomitant medications that interfere w/ CYP2C19. Avoid concomitant use w/ omeprazole or esomeprazole. Increased major bleeding in patients w/ recent transient ischemic attack/stroke using combination of aspirin & clopidogrel bisulfate. Should be used during pregnancy only if clearly needed. Discontinue nursing or discontinue the drug, taking into account the importance of therapy to the mother.
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Use In Pregnancy & Lactation
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Adverse Reactions
Bleeding, TTP.
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Drug Interactions
Reduced plasma conc of active metabolite & reduction in platelet inhibition w/ CYP2C19 inhibitors. Reduced antiplatelet activity w/ omeprazole or esomeprazole. Increased risk of GI bleeding w/ NSAIDs. Increased risk of bleeding w/ warfarin, SSRIs & SNRIs.
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Storage
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Description
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Action
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MIMS Class
Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics)
ATC Classification
B01AC04 - clopidogrel ; Belongs to the class of platelet aggregation inhibitors excluding heparin. Used in the treatment of thrombosis.
Regulatory Classification
Rx
Presentation/Packing
Form
Deplatt FC tab 75 mg
Packing/Price
100's (P3,304/pack)