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Signs and Symptoms: The most common signs and symptoms observed in adults exposed to hydrochlorothiazide are those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis. If a cardiac glycoside (eg, digoxin) or other antiarrhythmic drugs (eg, sotalol) has also been administered, hypokalemia may accentuate cardiac arrhythmias. The degree to which hydrochlorothiazide is removed by hemodialysis has not been established.
Management: Experience in adults exposed to irbesartan doses of up to 900 mg/day for 8 weeks revealed no toxicity. No specific information is available on the treatment of overdosage with CoAprovel. The patient should be closely monitored, and the treatment should be symptomatic and supportive, including fluid and electrolyte replacement. Suggested measures include induction of emesis and/or gastric lavage. Irbesartan is not removed from the body by hemodialysis.
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