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Use in pregnancy: Drugs that act directly on the renin-angiotensin system can cause fetal and neonatal morbidity and death when administered to pregnant women. When pregnancy is detected, irbesartan should be discontinued as soon as possible.
Use in lactation: Hydrochlorothiazide has been shown to pass into breast milk, while the excretion of irbesartan in breast milk has not yet been established. The American Academy of Pediatrics consider hydrochlorothiazide usually compatible with breastfeeding. Caution should be taken when administering Co-Ivyzar to lactating mothers.
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