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Hepatic/Renal Impairment: Hydrochlorothiazide should be used with caution on patients with these conditions. It should not be used when the creatinine clearance is <30 mL/min.
Use in lactation: Hydrochlorothiazide has been shown to pass into breast milk, while the excretion of irbesartan in breast milk has not yet been established. The American Academy of Pediatrics consider hydrochlorothiazide usually compatible with breastfeeding. Caution should be taken when administering Co-Ivyzar to lactating mothers.
Use in children: Pharmacokinetic parameters in pediatric subjects (6-16 years) were comparable to adults. At doses up to 150 mg daily for 4 weeks, irbesartan was well-tolerated in hypertensive children and adolescents.
Use in the elderly: While there is no overall differences in effectiveness or safety of irbesartan observed between these subjects and younger subjects, some older individuals are at risk in fluid and electrolyte balance due to hydrochlorothiazide. Use with caution on elderly.
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