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No data are available, in regard to overdosage in humans. However, daily doses of irbesartan 900 mg for 8 weeks were well-tolerated. The most likely manifestations of overdosage are expected to be hypotension and tachycardia; bradycardia might also occur from overdose. Irbesartan is not removed by hemodialysis.
The side effects of hydrochlorothiazide are a mixture of dose-dependent (primarily hypokalemia) and dose-dependent phenomena (eg, pancreatitis), the former much more common than the latter.
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