Cimex/Cimex Plus Drug Interactions

Cimex: Cefuroxime axetil is not bioequivalent and is therefore not substitutable on a mg/mg basis. Before therapy with cefuroxime axetil is instituted, careful inquiry should be made to determine whether the patients has had previous hypersensitivity reactions to cefuroxime axetil, other cephalosporins, penicillin or other drugs. If Cimex is to be given to penicillin-sensitive patients, caution should be exercised because cross-hypersensitivity among β-lactam antibiotics have been clearly documented and may occur up to 10% of patients with history of penicillin allergy. If a clinically significant allergic reaction to cefuroxime axetil occurs, discontinue the drug and institute appropriate therapy, serious acute hypersensitivity reactions may require treatment with epinephrine and other emergency measures, including oxygen, IV fluids, and IV antihistamines, corticosteroids, pressor amines and airway management as clinically indicated.
Pseudomembranous colitis has been reported with nearly all antibacterial agents, including cefuroxime and may range from mild to life-threatening. Therefore, it is important to consider this diagnosis in patients who present with diarrhea, subsequent to the administration of antibacterial agents.
Treatment with antibacterial agents alters the normal flora of the colon and may permit overgrowth or clostridia. Studies indicate that a toxin by Clostridium difficile is 1 primary cause of antibiotic-associated colitis.
After diagnosis of pseudomembranous colitis has been established, appropriate therapeutic measures should be initiated. Mild cases of pseudomembranous colitis usually respond to drug discontinuation alone. In moderate to severe cases, consideration should be given in the management with fluids and electrolytes, protein supplementation and treatment with an antibacterial drug effective against Clostridium difficile.
Suspension: Probenecid reduces the renal clearance of cefuroxime.
Cimex Plus: When cefuroxime combines with diuretics like furosemide or aminoglycoside antibiotic, renal disorder could be increased. Therefore, caution for renal function is required. When cefuroxime is administered to old aged or patients with history of renal disorder, monitoring of renal function is required.
Interference with Laboratory Test: Caution should be taken as urine test using Benedict's reagent, Fehling's reagent, Clinitest, except for testape reaction, may give false-positive results.
Caution should be taken as direct Coombs' test may give false-positive results.
As with the decreasing of copper level, urine test results can be changed.