Cimex/Cimex Plus Adverse Reactions

Cimex: FC tablet: These are usually mild in nature. Gastrointestinal disturbance including diarrhea, nausea and vomiting, and headache have been reported. Eosinophilia and transient increase of hepatic enzymes (SGPT, OT and LIH) have also been reported. Jaundice and Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, serum sickness-like reactions, anaphylaxis and angioedema have been reported rarely.
Oral suspension: Gastrointestinal disturbances including diarrhea, nausea and vomiting have occurred in some patients taking cefuroxime. There have been reports of erythema multiforme, Stevens-Johnson syndrome and toxic epidermal syndrome.
Cimex Plus: Shock: Shock may rarely occur. Therefore, cautious monitoring is required and if any abnormal sign is detected, further administration should be discontinued and appropriate measures should be taken.
Skin: Stevens-Johnson syndrome (mucocutaneous ocular syndrome), erythema multiforme, toxic epidermal necrotic syndrome. These symptoms may rarely occur. Therefore, cautious monitoring is required and if any abnormal sign is detected, further administration should be discontinued.
Hypersensitivity: Pruritus, shivering, exanthema (erythema, wheal), fever, urticaria, lymph node tumidity, arthrodynia, anaphylactic reaction.
Kidney: Severe renal disorder (interstitial nephritis, acute renal failure) These symptoms may rarely occur. Therefore, cautious monitoring is required and if abnormal sign is acknowledged, further administration should be discontinued and appropriate measures taken.
Blood: Rarely, decreased hemoglobin concentration, anemia, granulocytopenia, leukopenia, thrombocytopenia, occasionally neutropenia, hypoeosinophilia, thrombophlebitis may occur. Also it has been reported that with administration of cephalosporin antibiotics, hemolytic anemia occurred.
Liver: Abnormal liver function eg, elevation of ALT, AST and ALP may occasionally occur and elevation of bilirubin, γ-GPT may rarely occur.
Gastrointestinal System: Severe enterocolitis with hemafecia eg, pseudomembranous enterocolitis may rarely occur. If abnormal pain and frequent diarrhea occur, appropriate measures eg, immediate discontinuation of cefuroxime sodium be taken. Also nausea, diarrhea, rarely vomiting, anorexia may occasionally occur.
Respiratory System: Since interstitial pneumonia, pulmonary infiltration with eosinophilia (PIE) syndrome accompanied with fever, cough, dyspnea, abnormal chest x-ray, eosinophilia may rarely occur with other cephems. In case that such symptoms occur, further administration should be discontinued and appropriate measures eg, administration of adrenal cortical hormone should be taken.
Superinfection: Candidiasis intertrigo may rarely occur.
Vitamin Deficiency: Symptoms of vitamin K deficiency (hypoprothrombinemia, hemorrhage tendency) and vitamin B deficiency (glossitis, stomatitis, anorexia, neuritis) may rarely occur.
Others: Palsy may rarely occur. In the treatment of meningitis, especially in children, slight acoustic disorders occurred.