Cimex/Cimex Plus Dosage/Direction for Use

Cimex: FC tablet: Adults: Pharyngitis/Tonsillitis, Acute Sinusitis: 250-500 mg twice a day.
Acute Exacerbation of Chronic Bronchitis/Acute Bronchitis, Skin Infections: 250-500 mg twice daily.
Uncomplicated Gonorrhea: Single dose of 1 g is recommended.
Uncomplicated Urinary Tract Infection: 125 or 250-500 mg twice daily.
Oral suspension 125 mg/5 mL: Adults: 5-20 mL (1-4 tsp) twice daily.
Children >2 years: 10 mL (2 tsp) or 15 mg/kg body weight twice daily. Maximum Dose: 20 mL daily; >3 months: 5 mL (1 tsp) or 10 mg/kg body weight twice daily. Maximum Dose: 10 mL (2 tsp) daily.
Oral suspension 250 mg/5 mL: Adults: 5-10 mL (1-2 tsp) twice daily.
Children >2 years: 5 mL (1 tsp) or 15 mg/kg body weight twice daily. Maximum Dose: 10 mL (2 tsp) daily; >3 months: 2.5 mL (½ tsp) or 10 mg/kg body weight twice daily. Maximum Dose: 5 mL (1 tsp) daily.
Cimex Plus: Adults: 750 mg of cefuroxime sodium is administered IV or IM every 8 hrs but in more severe infections, 1.5 g is administered IV every 8 hrs. If necessary, it is administered IV or IM every 6 hrs but it should not exceed 3-6 g/day.
Infants and Children: A daily dose of 30-100 mg/kg body weight is administered IV or IM in 3 or 4 divided doses. Usually 60 mg/kg daily is suitable.
Neonates: A daily dose of 30-100 mg/kg is administered IV or IM in 2 or 3 divided doses. Cimex should be used cautiously because t_½ of cefuroxime sodium may be 3-5 times that of adults during 1 week after birth.
Gonorrhea: 1.5 g of cefuroxime sodium is administered IM or 750 mg of 1.5 g (potency) is administered to each side of buttock.
Renal Impairment: In patients with slightly impaired renal function, there is no need to reduce the dosage of cefuroxime sodium. But in case of severe renal function, (creatinine clearance between 10 and 20 mL/min) the dosage should only be given twice daily and in case of preterminal renal function (CrCl is low 10 mL/min) once daily. Patients undergoing hemodialysis should receive an additional 750 mg dose following each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg twice daily.
Perioperative Prophylaxis: Abdomen, Pelvis, Orthopedic Surgery: Usual Dose: 1.5 g of cefuroxime IV prior to the procedure; this may be supplemented by 750 mg (potency) IM after 8 and 16 hrs.
Heart, Lung, Esophagus, Vessel Surgery: Usual Dose: 1.5 g of cefuroxime IV prior to the procedure; this may be supplemented by 750 mg IM every 8 hrs for up to 24-84 hrs.
Total Joint Replacement: 1.5 g of cefuroxime powder may be mixed with the methylmethacrylate cement before addition of liquid monomer.
Meningitis: Adults: 3 g is administered IV every 8 hrs.
Infants and Children: A daily dose of 200-240 mg/kg body weight is administered IV in 3 or 4 divided doses; after clinical improvement for 3 days, dosage may be reduced to 100 mg/kg daily.
Neonates: An initial daily dose of 100 mg/kg is administered IV; after clinical improvement, dosage may be reduced to 50 mg/kg daily.