Sign Out
Pharmacology: Pharmacodynamics: Salbutamol: Salbutamol is a beta 2 adrenergic stimulant which has highly selective action on the receptors in the bronchial muscles, leading to bronchodilation. It has little or no action on the cardiac receptors.
Guaifenesin: Oral administration of guaifenesin facilitates expectoration by reducing mucus viscosity.
Pharmacokinetics: Salbutamol: Salbutamol is readily absorbed from the gastrointestinal tract. It is subject to first pass metabolism in the liver and possibly in the gut wall: The main metabolism is an inactive sulfate conjugate. It is rapidly excreted in the urine as metabolized and unchanged drug; there is some excretion in the faeces. It does not appear to be metabolized in the lung, therefore its ultimate metabolism and excretion following inhalation depends upon the delivery method used, which determines the proportion of inhaled salbutamol relative to the proportion inadvertently swallowed. It has been suggested that the majority of an inhaled dose is swallowed and absorbed from the gut.
The plasma half-life of salbutamol has been estimated to range from 4 to 6 hours.
Guaifenesin: Guaifenesin is absorbed from the gastrointestinal tract. It is metabolized then excreted in the urine.
Continue with Google