A few patients feel tense; this is also due to the effects on skeletal muscle and not to direct CNS stimulation.
With doses higher than those recommended or in patients who are usually sensitive to beta-adrenergic stimulants, peripheral vasodilation and a compensatory small increase in heart rate may occur.
Occasional headaches have been reported.
Salbutamol does not cause difficulty in micturition because unlike sympathomimetic drugs e.g. ephedrine, it does not stimulate alpha adrenoreceptors. Adverse effects associated with guaifenesin are rare.
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