Arbloc Dosage/Direction for Use

Losartan Potassium may be administered with or without food. It may also be administered with other antihypertensive agents.
Losartan is given by mouth as the potassium salt. The maximum hypotensive effect is achieved in about 3 to 6 weeks after initiating treatment.
Hypertension: The usual starting and maintenance dose is 50 mg once daily for most patients. The dose may be increased, if necessary, to 100 mg daily as a single dose or in two divided doses.
For elderly over 75 years and for patients with moderate to severe renal impairment (creatinine clearance less than 20 mL per minute), or intravascular fluid depletion, an initial dose of 25 mg once daily may be used. A reduced dose should also be considered for patients with hepatic impairment.
Hypertensive Patients with Left Ventricular Hypertrophy: The usual starting dose is 50 mg of Losartan Potassium once daily. A low dose of hydrochlorothiazide should be added and/or the dose of Losartan Potassium should be increased to 100 mg once daily based on blood pressure response.
Nephropathy in type 2 diabetic patients: The usual starting dose is 50 mg once daily. The dose may be increased to 100 mg once daily based on blood pressure response. Losartan Potassium may be administered with other antihypertensive agents like diuretics, calcium channel blockers, alpha- or beta-blockers, and centrally acting agents. It may be also administered with insulin and other commonly used hypoglycemic agents like sulfonylureas, glitazones and glucosidase inhibitors.