Appetite With Iron

Capsule: Pale cream to tan powder contained in empty gelatin capsule size #1 with scarlet body and black cap.
Each capsule contains: Retinol (Vitamin A) 3,000 IU, Cholecalciferol (Vitamin D₃) 300 IU, Thiamine mononitrate (Vitamin B₁) 15 mg, Riboflavin as sodium phosphate (Vitamin B₂) 1 mg, Nicotinamide (Vitamin B₃) 20 mg, Pyridoxine hydrochloride (Vitamin B₆) 5 mg, Cyanocobalamin (Vitamin B₁₂) 5 mcg, Iron (equivalent to 186 mg ferrous sulfate monohydrate) 60 mg, Buclizine hydrochloride 25 mg, Lysine hydrochloride 25 mg.
Syrup: Multivitamins + Iron + Buclizine Hydrochloride + Lysine Hydrochloride (Appetite with Iron) is a red to dark brown syrup with a wildberry odor and flavor having a wildberry sour sweet and iron taste.
Each 5 mL (1 teaspoonful) contains: Thiamine hydrochloride (Vitamin B₁) 15 mg, Riboflavin sodium phosphate (Vitamin B₂) 1 mg, Nicotinamide (Vitamin B₃) 20 mg, Pyridoxine hydrochloride (Vitamin B₆) 5 mg, Cyanocobalamin (Vitamin B₁₂) 5 mcg, Iron (equivalent to 75 mg ferrous sulfate heptahydrate) 15 mg, Buclizine hydrochloride 5 mg, Lysine hydrochloride 100 mg.

Capsule: Pharmacology: Pharmacodynamics: Vitamin A is effective for the treatment of Vitamin A deficiency. Vitamin A refers to a group of fat-soluble substances that are structurally related to and possess the biological activity of the parent substance of the group called all-trans retinol or retinol. Vitamin A plays vital roles in vision, epithelial differentiation, growth, reproduction, pattern formation during embryogenesis, bone development, hematopoiesis and brain development. It is also important for the maintenance of the proper functioning of the immune system.
Cholecalciferol is a steroid hormone produced in the skin when exposed to ultraviolet light or obtained from dietary sources. The active form of cholecalciferol, 1,25-dihydroxycholecalciferol (calcitriol) plays an important role in maintaining blood calcium and phosphorus levels and mineralization of bone. The activated form of cholecalciferol binds to vitamin D receptors and modulates gene expression. This leads to an increase in serum calcium concentrations by increasing intestinal absorption of phosphorus and calcium, promoting distal renal tubular reabsorption of calcium and increasing osteoclastic resorption.
Thiamine is a vitamin required in cellular aerobic metabolism, cell growth, nerve impulse transmission and production of acetylcholine.
Riboflavin is an essential human nutrient that is a heat-stable and water-soluble flavin belonging to the vitamin B family. Riboflavin is a precursor of the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). These coenzymes are of vital importance in normal tissue respiration, pyridoxine activation, tryptophan to niacin conversion, fat, carbohydrate, and protein metabolism, and glutathione reductase mediated detoxification. Riboflavin may also be involved in maintaining erythrocyte integrity. This vitamin is essential for healthy skin, nails, and hair.
Nicotinamide is the active form of vitamin B₃ and a component of the coenzyme nicotinamide adenine dinucleotide (NAD). Nicotinamide acts as a chemo- and radio-sensitizing agent by enhancing tumor blood flow, thereby reducing tumor hypoxia. This agent also inhibits poly (ADP-ribose) polymerases, enzymes involved in the rejoining of DNA strand breaks induced by radiation or chemotherapy.
Pyridoxine hydrochloride is the hydrochloride salt form of pyridoxine, a water-soluble vitamin B. Pyridoxine hydrochloride is converted into the active form, pyridoxal 5'-phosphate (PLP), an essential cofactor in many enzymatic activities including synthesis of amino acids, neurotransmitters, and sphingolipids. This vitamin is essential to red blood cell, nervous system, and immune systems functions and helps maintain normal blood glucose levels.
Cyanocobalamin or vitamin B₁₂ is a water-soluble organometallic compound containing a trivalent cobalt ion bound to a corrin ring. Vitamin B₁₂ is an essential coenzyme in nucleic acid synthesis as well as nerve functions and blood cell production. Adult recommended requirements is about 1 to 2 micrograms per day.
Ferrous sulfate replenishes iron, an essential component in hemoglobin, myoglobin, and various enzymes. It replaces the iron that is usually found in hemoglobin and myoglobin. Iron participates in oxygen transport and storage, electron transport and energy metabolism, antioxidant and beneficial pro-oxidant functions, oxygen sensing, tissue proliferation and growth, as well as DNA replication and repair.
Buclizine is a piperazine-derivative antihistamine used as an antivertigo/antiemetic agent. Buclizine is used in the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness. Additionally, it has been used in the management of vertigo in diseases affecting the vestibular apparatus.
Lysine belongs to one of the nine essential amino acids in humans. Amino acids serve as the building blocks of protein and are important for growth and tissue repair. Unlike the non-essential amino acids, essential amino acids are not synthesized by the human body and are usually supplied from dietary sources.
Pharmacokinetics: Absorption: Retinol (Vitamin A): Retinol is readily absorbed from the normal gastrointestinal tract.
Cholecalciferol (Vitamin D3): Cholecalciferol is readily absorbed from the small intestine if fat absorption is normal. Moreover, bile is necessary for absorption as well.
Thiamine (Vitamin B₁): Small amounts of thiamine are well absorbed from the gastrointestinal tract after oral doses.
Riboflavin (Vitamin B₂): Riboflavin is readily absorbed from the gastrointestinal tract.
Nicotinamide (Vitamin B₃): Nicotinamide is readily absorbed from the gastrointestinal tract after oral doses.
Pyridoxine (Vitamin B₆): Pyridoxine is readily absorbed from the gastrointestinal tract after oral doses.
Cyanocobalamin (Vitamin B₁₂): Vitamin B₁₂ substances bind to intrinsic factor, a glycoprotein secreted by the gastric mucosa, and are then actively absorbed from the gastrointestinal tract.
Ferrous sulfate (Iron): Iron is irregular and incompletely absorbed from the gastrointestinal tract, the main sites of absorption being the duodenum and jejunum.
Buclizine: Buclizine is rapidly absorbed following oral administration.
Lysine: Free amino acids, including free lysine, are absorbed in the small intestines.
Free amino acids in the intestinal lumen are transported into the mucosal cells by an amino acid-specific carrier system. The amino acids are then secreted out to the portal circulation.
Distribution: Retinol (Vitamin A): Less than 5% of circulating vitamin A is bound to lipoproteins in blood in normal condition but may be up to 65% when hepatic stores are saturated because of excessive intake. When released from liver, vitamin A is bound to retinol-binding protein (RBP). Most vitamin A circulates in the form of retinol bound to RBP.
Cholecalciferol (Vitamin D₃): Studies have determined that the mean central volume of distribution of administered cholecalciferol supplementation in a group of 49 kidney transplant patients was approximately 237 L.
Thiamine (Vitamin B₁): Thiamine is widely distributed to most body tissues and appears in breastmilk.
Riboflavin (Vitamin B₂): About 60% of FMN and FAD are bound to plasma proteins.
Nicotinamide (Vitamin B₃): Nicotinamide is widely distributed in the body tissues.
Pyridoxine (Vitamin B₆): Pyridoxine is mainly stored in the liver with lesser amounts in muscle & brain.
Cyanocobalamin (Vitamin B₁₂): Vitamin B₁₂ is released from food and salivary binding protein and bound to gastric intrinsic factor. When the vitamin B₁₂ intrinsic factor complex reaches the ileum, it interacts with the receptor on the mucosal cell surface and is actively transported into circulation.
Ferrous sulfate (Iron): Most of absorbed iron is bound to transferrin and transported to the bone marrow where it is incorporated into hemoglobin. The remainder is contained within the storage forms, ferritin, or hemosiderin, or as myoglobin, with smaller amounts occurring in heme containing enzymes or in plasma bound to transferrin.
Buclizine: Buclizine is rapidly absorbed following oral administration.
Lysine: The free amino acids in the portal circulation will pass through the liver, a portion of which will be utilized. The remaining amino acids are then transported to the systemic circulation for utilization by the peripheral tissues.
Metabolism: Retinol (Vitamin A): Retinol undergoes hepatic metabolism. Retinol is conjugated with glucuronic acid; the B-glucuronide undergoes enterohepatic circulation and oxidation to retinol and retinoic acid. Retinoic acid undergoes decarboxylation and conjugation with glucuronic acid.
Cholecalciferol (Vitamin D₃): Within the liver, cholecalciferol is hydroxylated to calcifediol (25-hydroxycholecalciferol) by the enzyme vitamin D-25-hydroxylase. At the kidney, calcifediol subsequently serves as a substrate for 1-alpha-hydroxylase, yielding calcitriol (1,25-dihydroxycholecalciferol), the biologically active form of vitamin D3.
Thiamine (Vitamin B₁): Thiamin from dietary supplements is absorbed by the small intestine through active transport at nutritional doses and by passive diffusion at pharmacologic doses.
Riboflavin (Vitamin B₂): Riboflavin is converted in the body to the coenzyme flavin mononucleotide and then to another coenzyme flavin adenine dinucleotide (FAD).
Nicotinamide (Vitamin B₃): Niacin is converted in the body to the amide, which is incorporated into niacinamide adenine dinucleotide (NAD).
Pyridoxine (Vitamin B₆): After oral administration of pyridoxine, it is converted into active forms pyridoxal phosphate and pyridoxamine phosphate. Pyridoxine is oxidized in the liver to form 4-pyridoxic acid and other inactive metabolites.
Cyanocobalamin (Vitamin B₁₂): Vitamin B₁₂ is extensively bound to plasma proteins transcobalamin. Transcobalamin II appears to be involved in the rapid transport of the cobalamins to tissues.
Ferrous sulfate (Iron): Absorption of iron is aided by the acid secretion of the stomach and by some dietary acids (such as ascorbic acid) and occurs more readily when iron is in the ferrous state or is part of the heme complex (heme-iron).
Lysine: Lysine is metabolized via protein synthesis or oxidative catabolism. During protein synthesis, lysine is utilized for the formation of substances such as carnitine, collagen and elastin. With oxidative catabolism, lysine is broken down to products that can be further used for the biosynthetic pathways for glucose and fat.
Excretion: Retinol (Vitamin A): Vitamin A is excreted via the feces and urine and has a half-life of 1.9 hours.
Cholecalciferol (Vitamin D₃): It has been observed that administered cholecalciferol and its metabolites are excreted primarily in the bile and feces.
Thiamine (Vitamin B₁): In excess amount of thiamine in the body's requirement are excreted in the urine unchanged or as metabolites.
Riboflavin (Vitamin B₂): Riboflavin is excreted in urine, partly as metabolites.
Nicotinamide (Vitamin B₃): Small amount of nicotinamide is excreted unchanged in urine after therapeutic doses; The amount excreted unchanged is increased with larger doses.
Pyridoxine (Vitamin B₆): Pyridoxine is excreted in urine.
Cyanocobalamin (Vitamin B₁₂): Vitamin B₁₂ is excreted in the bile and undergoes extensive enterohepatic recycling and part of a dose is excreted in the urine.
Ferrous sulfate (Iron): A very small amount of iron is excreted as the majority is released after the destruction of the hemoglobin molecule is re-used.
Lysine: Nitrogen is excreted through the urine mostly in the form of urea. Urea is the end product of amino acid catabolism.

Capsule: As a nutritional supplement to improve appetite and weight gain and for the prevention and treatment of deficiencies in vitamin A, vitamin B-complex, vitamin D, and iron.
Syrup: This medicine is used as a nutritional supplement to improve appetite and weight gain and for the prevention and treatment of deficiencies in vitamin B-complex and iron.

Capsule: For oral administration.
Adult Dose: One (1) capsule twice a day. Dosage may be increased depending on the patient's need or as prescribed by the physician.
Recommended to be taken on an empty stomach (1 hour before or 2 hours after meals) for better iron absorption. May be taken with food if stomach upset occurs.
Syrup: For oral administration.
2-6 years old: 5 mL (1 teaspoonful).
7-14 years old: 10 mL (2 teaspoonfuls).
Above 14 years old: 15 mL (1 tablespoonful).
To be taken once daily or as prescribed by a physician.
Missed dose: Syrup: If the patient missed a dose, just continue taking the recommended dose per day.

Capsule: Retinol (Vitamin A): Acute ingestion of more than 12,000 IU/kg is considered toxic. Chronic ingestion of more than 25,000 IU/d for 2-3 weeks may produce toxicity. Acute toxicity causes rash, abdominal pain, increased intracranial pressure, and vomiting. Chronic toxicity causes rash, increased intracranial pressure, sparse and coarse hair, dry and rough skin, and arthralgia; risk of fractures is increased, especially in the elderly.
Cholecalciferol (Vitamin D₃): Acute ingestion is highly unlikely to produce toxicity. In children, chronic ingestion of more than 5,000 IU/d for several weeks may result in toxicity (adults >25,000 IU/d). Despite its safety, excessive use can lead to vitamin D toxicity, which manifests with nausea, vomiting, decreased appetite, fatigue, weight loss, constipation, dehydration, irritability, and confusion. Those symptoms are still observable for more than two months after drug discontinuation and largely derive from the effects of hypercalcemia.
Acute intake of large doses of water-soluble vitamins is readily excreted in the urine. No emergency procedure or antidote is applicable, and any symptoms are rapidly reduced upon withdrawal of the preparation. However, the following adverse reactions have been reported: Thiamine (Vitamin B₁): Thiamine doses of 5 mg/day for 4 to 5 weeks may cause headache, insomnia, irritability, increased heart rate, and weakness.
Riboflavin (Vitamin B₂): Large doses of riboflavin result in a bright yellow discoloration of the urine that may interfere with certain laboratory tests.
Nicotinamide (Vitamin B₃): An intake of 3,000 mg/day of vitamin B₃ may cause nausea, vomiting and signs of liver toxicity.
Pyridoxine (Vitamin B₆): Reversible sensory neuropathy has been reported with chronic intake of high doses of vitamin B₆; the dose at which these occur is controversial.
Cyanocobalamin (Vitamin B₁₂): High doses of cyanocobalamin are generally not associated with toxicity although rare allergic and anaphylactic reactions and mild diarrhea have occurred.
Ferrous sulfate (Iron): Iron overload may result to pigment deposition in skin and other organs, mild liver dysfunction, endocrine dysfunction, heart disease and severe damage to the gastrointestinal tract.
Oral intake of 20 to 60 mg/kg elemental iron may or may not produce serious toxicity symptoms. Oral doses of 40 to 60 mg/kg are associated with serious toxicity. Fatality has been reported with doses 60 to 300 mg/kg.
Iron toxicity clinically manifests in five overlapping phases. The first is the gastrointestinal phase that occurs 30 mins to 6 hours post ingestion. Clinical presentation results from direct injury to the gastrointestinal mucosa and may include abdominal pain, vomiting, diarrhea, hematemesis, melena, and lethargy. The next phase is the latent phase or the relative stability phase which occurs after 6 to 24 hours. The third phase is characterized by shock and metabolic acidosis and typically occur within 6 to 72 hours post ingestion. Shock may be due to hypovolemia or direct cardiotoxicity. The fourth phase is hepatotoxicity or hepatic necrosis which may be expected within 12 to 96 hours. Hepatocellular necrosis should be suspected when jaundice, bleeding, hypoglycemia, encephalopathy, and positive anion gap metabolic acidosis are evident. Renal failure may ensue with poor tissue perfusion. The fifth phase is bowel obstruction which can present 2 to 8 weeks after ingestion. This result from stricture or pyloric stenosis brought about by gastric scarring. Clinical evaluation together with appropriate laboratory analysis are important in the clinical assessment as there is no single satisfactory method of evaluation of iron toxicity. Determining the serum iron concentration (SIC) approximately 4 to 6 hours after ingestion may be the best laboratory parameters of severity. (See table.)

Click on icon to see table/diagram/image

Elemental iron toxicity should be managed with aggressive supportive care. Whole bowel irrigation should be done whenever possible. Correct metabolic acidosis with adequate fluid resuscitation and administration of sodium bicarbonate. The antidote of choice is intravenous deferoxamine. Deferoxamine should be considered among patients with severe symptoms (altered mental status, hemodynamic instability, persistent vomiting and/or diarrhea), anion gap metabolic acidosis or peak serum iron concentration of 5 mg/L (90 micromol/L) or higher. Hemodialysis may be considered in acute renal failure to facilitate the removal of iron-deferoxamine complexes.
Buclizine: Antihistamine overdose in general can include dizziness, tachycardia, headache, drowsiness, or agitation. While the current generation of lesser sedating antihistamines do not affect the QT interval at normal doses, there are concerns there may be some effect in overdose.
Syrup: Excessive intake of this medicine may cause headache, insomnia, irritability, increased heart rate, weakness, bright yellow urine, nausea, vomiting, signs of liver toxicity, numbness, allergic reactions, diarrhea, abdominal problems, acute renal failure, dizziness, excitability, drowsiness, anxiety, black colored stool, and vomiting of blood.
What to do when the patient has taken more than the recommended dosage: Consult the doctor immediately if the patient experiences any of the signs and symptoms of overdose. (See as previously mentioned.)

Capsule: Known hypersensitivity to the active components or any of the excipients.
Hypercalcemia.
Severe renal impairment of renal failure.
Patient with hemochromatosis, receiving blood transfusions, patients with peptic ulcer, ulcerative colitis, and regional enteritis.
Syrup: Do not take this medicine if the patient has an allergy to any of the ingredients of this product (see Description).

Capsule: Nicotinamide (Vitamin B₃) in large doses should be used with caution in patients with gallbladder disease or diabetes. Nicotinamide may elevate uric acid levels, use with caution in patients predisposed to gout. Nicotinamide should be avoided in most patients with severe peptic ulcer.
Vitamin D should be used with caution in patients with impairment of renal function and the effect on calcium and phosphate levels should be monitored.
Administration of vitamin A in patients with renal disease is contraindicated as the clearance of vitamin A is low, which may lead to vitamin A toxicity.
Buclizine may cause drowsiness and patients taking the drug should be cautioned against engaging in activities like driving and use of machineries.
Oral iron preparation may cause gastrointestinal irritation and abdominal pain with nausea, vomiting, diarrhea, or constipation. Administration of iron for more than six months should be avoided except in patients with continued bleeding, menorrhagia, or repeated pregnancies; avoid in patients with peptic ulcer, enteritis, or ulcerative colitis.
Use cautiously in long-term therapy.
Do not take more than the recommended dose. Keep out of reach of children as overdose may be fatal.
Syrup: Do not take more than the recommended dosage unless prescribed by a physician.
Keep out of reach of children as overdose may be fatal.
When should a patient consult a doctor: Consult the doctor if the patient experiences any undesirable effects. (See Adverse Reactions.)

Pregnancy: Capsule: Excessive doses of preformed vitamin A are teratogenic, as may be marked maternal deficiency. In addition, recent evidence has demonstrated that severe maternal vitamin A deficiency may increase the risk of mother-to-child HIV transmission and reduced infant growth during the first year.
The recommended dietary allowance (RDA) of vitamin A for normal pregnant women is 900 IU, and the tolerable upper limit intake (UL) is 2800-3000 IU. Because of the teratogenic effects secondary to excessive vitamin A intake, the WHO recommends as safe during pregnancy a maximum dose of up to 10,000 IU daily or 25,000 IU weekly after the first 60 days of gestation.
The recommended dietary allowance (RDA) of vitamin D for normal pregnant women is 400 IU, and the tolerable upper limit intake (UL) is 2000-4000 IU. Large doses of vitamin D should not be used during pregnancy unless the clinical condition of the woman requires treatment with cholecalciferol, at a dose necessary to overcome the deficiency.
Based on human experience and animal studies, vitamin D overdose causes physical and mental disability and congenital heart and eye conditions, due to hypercalcemia, when administered during pregnancy.
Clinical data with use of buclizine in humans are not adequate to establish safety during pregnancy. Although experiments in some animals gave rise to adverse effects following the administration of buclizine to pregnant animals.
Lactation: Capsule: Vitamins A and B are expressed in breastmilk. Very large doses of vitamin B₆ have been reported to suppress lactation.
Cholecalciferol (vitamin D) and its metabolites are excreted in breastmilk. Overdose in infants induced by nursing mothers has not been observed. However, when prescribing additional vitamin D to a breast-fed child, the practitioner should consider the dose of any additional vitamin D given to the mother.
Maternal dietary iron appears to have little effect on human milk iron concentration.
Due to the limited safety information of this product during pregnancy and lactation, consider using this product only if the benefit outweighs the risk.

Capsule: The safety information is based on the individual components since there is limited information for the combination of multivitamins, iron, buclizine hydrochloride, and lysine hydrochloride.
Retinol (Vitamin A): Vitamin A toxicity, initially presenting with irritability, vomiting, loss of appetite and skin changes, has been reported especially in children.
Cholecalciferol (Vitamin D₃): Although rare, cholecalciferol has a few adverse effects that include hypercalcemia, hypercalciuria which could lead to nephrolithiasis, nephrotoxicity, and hyperphosphatemia.
Vitamin B: Adverse events with B vitamins are rare although peripheral sensory neuropathy, hypersensitivity reactions, constipation, vomiting, and abdominal pain have been reported.
Ferrous sulfate (Iron): Adverse events with the use of iron includes hypersensitivity reactions, flatulence, diarrhea, nausea and vomiting, abdominal pain, and black stool discoloration.
Buclizine: Adverse drug reactions on buclizine includes drowsiness, dryness of mouth, headache, and jitteriness.
Syrup: Adverse events with B vitamins, iron, buclizine hydrochloride, and lysine hydrochloride are rare although numbness, hypersensitivity reactions, constipation, vomiting, abdominal pain, black stool discoloration, bright yellow urine, drowsiness, dryness of mouth, headache, and jitteriness have been reported.

Capsule: Retinol (Vitamin A): Contraceptive pills raise the plasma levels of Vitamin A.
Chronic excessive alcohol consumption increases the risk of vitamin A hepatotoxicity.
Neomycin can markedly reduce the absorption of vitamin A from the gut.
Long-term use of vitamin A or taking high doses may increase the risk of bleeding for those taking blood-thinning medications, particularly warfarin.
Simultaneous treatment with ion exchange resins such as cholestyramine or laxatives such as paraffin oil may reduce the gastrointestinal absorption of the vitamin.
Cholecalciferol (Vitamin D₃): Vitamin D increases calcium gastrointestinal absorption.
Vitamin D should not be given in patients taking the following: paricalcitol, calcipotriene, doxercalciferol, mineral oil, orlistat, and bile acid sequestrants like colesevelam, colestipol, cholestyramine.
Co-administration of benzothiadiazine derivatives (thiazide diuretics) increases the risk of hypercalcemia because they decrease the calcium excretion in the urine. The calcium levels in plasma and urine should therefore be monitored for patients undergoing long-term treatment.
Anticonvulsants such as phenytoin, phenobarbital, primidone may diminish the effect of cholecalciferol due to hepatic enzyme induction.
Thiamine (Vitamin B₁): Fluorouracil increases thiamin metabolism and block the formation of thiamine pyrophosphate that could further exacerbate pre-existing thiamine deficiency in cancer patients.
Pyridoxine (Vitamin B₆): Vitamin B₆ reduces the effects of levodopa, but this does not occur if a dopa decarboxylase inhibitor is also given.
High doses of vitamin B₆ can decrease serum concentration of phenytoin and phenobarbital.
Vitamin B₆ can reduce the effectiveness of altretamine (hexamethyl melamine).
Cyanocobalamin (Vitamin B₁₂): Aspirin, proton pump inhibitors, H2-receptor antagonists, neomycin, and colchicine can reduce the absorption of vitamin B₁₂ from the gut.
Intake of chloramphenicol may cause a milder, reversible bone marrow depression which can oppose the treatment of anemias with vitamin B₁₂.
Ferrous sulfate (Iron): The absorption of iron and the expected hematological response to iron can be reduced by the concurrent use of antacids.
Beverage high in polyphenolics may reduce iron absorption.
Intake of chloramphenicol may cause a milder, reversible bone marrow depression which can oppose the treatment of anemias with iron.
Neomycin may alter the absorption of iron.
Iron reduces the absorption of penicillamine, tetracycline, cefdinir, methyldopa, levodopa, quinolone antibiotics (ciprofloxacin, ofloxacin, norfloxacin and moxifloxacin) and levothyroxine through chelate formation.
Buclizine: Buclizine may enhance the sedative effect of nervous depressants including alcohol, barbiturates, hypnotics, narcotics, analgesic, sedatives, and tranquilizers.
Syrup: Consult the doctor first if the patient is taking fluorouracil, levodopa, anticonvulsants, altretamine, aspirin, proton pump inhibitors, H2-receptor antagonists, neomycin, colchicine, chloramphenicol, antacids, penicillamine, tetracycline, cefdinir, methyldopa, quinolone antibiotics, levothyroxine, and nervous depressants like alcohol, barbiturates, hypnotics, narcotics, analgesic, sedatives, and tranquilizers.
Avoid drinking coffee, tea, or red wine while taking this medicine.

Store at temperatures not exceeding 30°C.

Appetite Enhancers

R06AE51 - buclizine, combinations ; Belongs to the class of piperazine derivatives used as systemic antihistamines.

Cap: Rx; Syr: Non-Rx