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Pregnancy: (Pregnancy Category D) Aminoglycosides can cause fetal harm when administered to pregnant women, but potential benefits from use of the drugs may be acceptable in certain conditions despite possible risks to the fetus. Aminoglycosides should be used during pregnancy only in life-threatening situations or severe infections for which safer drugs cannot be used or are ineffective.
Lactation: It is not known whether amikacin is excreted in human milk. Since many drugs are excreted in human milk and because of potential serious adverse reactions from amikacin in breastfeeding infants, a decision should be made whether to discontinue breastfeeding or to discontinue the drug, taking into account the importance of the drug to the mother.
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