Amikacide Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Amikacin sulfate

Indications/Uses

Bacterial septicemia including neonatal sepsis. Serious infections of the resp tract. Infections of the bone & joints. Intra-abdominal infections including peritonitis. Burns & post-op infections. Serious & complicated UTI due to susceptible organisms. As initial therapy in suspected gm -ve infections before the results of susceptibility testing are obtained.

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Dosage/Direction for Use

Adult, childn & older infant 15 mg/kg/day given as a single dose or divided into 2-3 equal doses administered at equally divided intervals. Uncomplicated UTI Single dose of 500 mg daily or 250 mg bid. Newborn Loading dose: 10 mg/kg, followed by 7.5 mg/kg every 12 hr; 0-7 days, <2 kg 7.5 mg/kg every 18-24 hr for 7-10 days. Peritoneal dialysis 7.5 mg/kg. Renal impairment CrCl >80 mL/min 15 mg/kg every 24 hr, 60-80 mL/min 12 mg/kg every 24 hr, 40-60 mL/min 7.5 mg/kg every 24 hr, 30-40 mL/min 4 mg/kg every 24 hr, 20-30 mL/min 7.5 mg/kg every 48 hr, 10-20 mL/min 4 mg/kg every 48 hr, <10 mL/min 3 mg/kg every 72 hr.

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Overdosage

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Contraindications

Hypersensitivity to aminoglycosides.

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Special Precautions

Avoid concurrent use w/ other ototoxic or nephrotoxic agents. Observe for signs of 8th cranial nerve damage during therapy. Assess kidney function prior to starting therapy & daily during the course of treatment. Increase hydration if signs of renal irritation appear. Stop treatment if azotemia increases or if progressive decrease in urinary output occurs. Patients w/ neuromuscular disorders eg, myasthenia gravis or parkinsonism. Overgrowth of nonsusceptible organisms. Contains metabisulfite. Pregnancy & lactation. Premature neonates. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Auditory, vestibular, renal toxicity & neuromuscular blockade. Hearing loss, loss of balance; acute muscular paralysis, apnea; elevated serum creatinine, albuminuria, presence of casts, RBC & WBC in urine, azotemia, oliguria.

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Drug Interactions

Avoid concurrent &/or sequential use w/ other drugs w/ similar toxic potential (eg, other aminoglycosides, acyclovir, amphotericin B, bacitracin, capreomycin, cephalosporins, colistin, cisplatin, methoxyflurane, polymyxin B, vancomycin). Increased risk of ototoxicity w/ ethacrynic acid, furosemide, urea, mannitol. May potentiate neuromuscular blockade & cause resp paralysis w/ general anesth of neuromuscular blocking agents (eg, succinylcholine, tubocurarine). May potentiate effects of oral anticoagulants w/ oral neomycin. Additive or synergistic effect w/ β-lactam antibiotics or vancomycin & extended-spectrum penicillins.

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Caution For Usage

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Storage

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Description

View Amikacide description for details of the chemical structure and excipients (inactive components).

Action

View Amikacide mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Aminoglycosides

ATC Classification

J01GB06 - amikacin ; Belongs to the class of other aminoglycosides. Used in the systemic treatment of infections.

Regulatory Classification

Presentation/Packing

Form

Amikacide inj 125 mg/mL

Packing/Price

2 mL x 5 × 1's (P2,139.4/box)

Form

Amikacide inj 250 mg/mL

Packing/Price

2 mL x 5 × 1's (P3,453.55/box)

Form

Amikacide inj 50 mg/mL

Packing/Price

(amp) 2 mL x 5 × 1's (P1,007.73/box)

Amikacide

amikacin

Manufacturer:

UNILAB, Inc

Distributor:

UNILAB, Inc