Amikacide Caution For Usage

Preparation of solution for IV infusion: Add the contents of a 100, 250 or 500 mg ampule to 100 or 200 mL of sterile diluent such as Normal Saline or any of the compatible solutions listed as follows.
Adults: The solution is administered over a 30 to 60 minute period. The total daily dose should not exceed 15 mg/kg/day and may be given as a single dose or in 2 or 3 equally divided doses at equally divided intervals.
Children: The amount of fluid used will depend on the amount ordered for the patient. It should be a sufficient amount to infuse amikacin over a 30 to 60 minute period. Infants should receive a 1 to 2 hour infusion.
Inspect visually for particulate matter and discoloration prior to administration.
Do not premix amikacin with other drugs. It should be administered separately according to the recommended dose and route.
Discard unused portion after opening the ampule.
Compatibility, Storage and Stability: Amikacin is stable in 24 hours at room temperature at concentrations of 0.25 and 5 mg/mL in the following solutions: 5% Dextrose Injection, 5% Dextrose and 0.2% Sodium Chloride Injection, 5% Dextrose and 0.45% Sodium Chloride Injection, 0.9% Sodium Chloride Injection, Lactated Ringer's Injection, Normosol M in 5% Dextrose Injection, Normosol R in 5% Dextrose Injection.
Cutting Instruction: Without using any file: hold the ampule body in an upright position with one hand.
Place the right or left index finger on the one-color dot.
Apply thumb pressure on the bulb opposite the one-color dot.
Snap-break away from the body.
Discard unused portion after opening the ampule.