Klacid Hp Drug Interactions

Klacid: The use of the following drugs is strictly contraindicated due to the potential for severe drug interaction effects: Cisapride, domperidone, pimozide, astemizole and terfenadine, ergot alkaloids, oral midazolam, HMG CoA Reductase Inhibitors (statins). Effects of Other Medicinal Products on Clarithromycin: Efavirenz, nevirapine, rifampicin, rifabutin and rifapentine, Etravinine, Fluconazole, Ritonavir, Effect of Clarithromycin on Other Medicinal Products; Antiarrhythmics, Oral hypoglycemic agents/ Insulin, CYP3A-based Interactions, Omeprazole, Sildenafil, tadalafil, and vardenafil, Theophylline, carbamazepine, Tolterodine, Triazolobenzodiazepines (e.g., alprazolam, midazolam, triazolam), Other drug interactions; Colchicine, Digoxin, Zidovudine, Phenytoin and valproate, Bi-directional drug interactions; Atazanavir, Calcium channel blockers, Itraconazole, Saquinavir.
Controloc: Controloc may reduce the absorption of drugs whose bioavailability is pH-dependent (e.g. ketoconazole). Pantoprazole is metabolised in the liver via the cytochrome P450 enzyme system. An interaction of pantoprazole with other drugs or compounds which are metabolised using the same enzyme system cannot be excluded. No clinically significant interactions were, however, observed in specific tests with a number of such drugs or compounds, namely carbamazepine, caffeine, diazepam, diclofenac, digoxin, ethanol, glibenclamide, metoprolol, nifedipine, phenprocoumon, phenytoin, theophylline, warfarin and an oral contraceptive. There werealso nointeractions with concomitantly administered antacids. Human kinetic interaction studies have been performed administering pantoprazole concomitantly with the respective antibiotics (clarithromycin, metronidazole, amoxycillin). No clinically relevant interactions were found.
Ospamox: Concomitant ingestion of allopurinol may promote the occurrence of skin rashes. The underlying mechanisms is still poorly understood. As penicillins like amoxycillin only act on proliferating microorganisms, they should not be combined with bacteriostatic antibiotics e.g. tetracyclines and chloramphenicol. If suggested by the outcome of susceptibility tests, combinations with other bactericidal antibiotics (cephalosporins, aminoglycoside) may be used. The concomitant administration of probenecid (e.g. 0.5gm qid orally); contraindicated in children below age 2 years produces sustained and higher plasma level by suppressing renal elimination. Conversely, tissue distribution and diffusion of Ospamox may be reduced by probenecid. Like other antibiotics, aminopenicillin may rarely reduce the efficacy of oral contraceptives. Concomitant antacid intake reduces amoxycillin absorption. Non-enzymatic urinary glucose tests may be false positive. Urobilinogen tests may also be impaired.