Klacid Hp Contraindications

Klacid: is hypersensitivity to macrolide antibiotic drugs or any of the excipients. Concomitant administration of clarithromycin and any of the following drugs is contraindicated: astemizole, cisapride, domperidone, pimozide, terfenadine as this may result in QT prolongation and cardiac arrhythmias including ventricular tachycardia, ventricular fibrillation, and torsades de pointes. Concomitant administration of clarithromycin and ergot alkaloids (e.g., ergotamine or dihydroergotamine) is contraindicated, as this may result in ergot toxicity. Concomitant administration of clarithromycin and oral midazolam is contraindicated. Clarithromycin should not be given to patients with history of QT prolongation (congenital or documented acquired QT prolongation) or ventricular cardiac arrhythmia, including torsades de pointes. Clarithromycin should not be given to patients with hypokalemia (risk of prolongation of QT-time).Clarithromycin should not be used in patients who suffer from severe hepatic failure in combination with renal impairment. Clarithromycin should not be used concomitantly with HMG-CoA reductase inhibitors (statins) that are extensively metabolized by CYP3A4 (lovastatin or simvastatin), due to the increased risk of myopathy, including rhabdomyolysis. Clarithromycin (and other strong CYP3A4 inhibitors) should not be used concomitantly with colchicine. Concomitant administration with ticagrelor or ranolazine is contraindicated.
Controloc: should not be used in cases of known hypersensitivity to one of the constituents of Controloc or the combination partners. Controloc must not be used in combination treatment for eradication of H. pylori patients with moderate to severe hepatic or renal dysfunction since currently no data are available on the efficacy and safety of Controloc in combination treatment of these patients.
Ospamox: known and suspected hypersensitivity to penicillins. Potential cross allergy should be considered in patients with cephalosporin hypersensitivity. Because of the increased incidence of side effects (rashes) amoxycillin should not be administered to patients with mononucleosis and lymphatic leukemia. Severe gastro-intestinal infections with persistent diarrhea or vomiting should not be treated with oral amoxycillin because of the risk of reduced absorption. Special caution should be exercised in patients with allergic diatheses or bronchial asthma and hay fever.