Aklief Special Precautions

Erythema, scaling, dryness, and stinging/burning may be experienced with use of Aklief cream (see Adverse Reactions). To mitigate the risk of such reactions, patients should be instructed to use a moisturiser from the initiation of treatment, and, if appropriate, reduce the frequency of application of Aklief cream, or suspend use temporarily. Despite mitigation measures, if severe reactions persist the treatment may be discontinued.
The product should not be applied to cuts, abrasions, eczematous or sunburnt skin.
As with other retinoids, use of "waxing" as a depilatory method should be avoided on skin treated with Aklief.
If a reaction suggesting sensitivity to any component of the formula occurs, the use of Aklief should be discontinued. Caution should be exercised if cosmetics or acne medications with desquamative, irritant or drying effects are concomitantly used with the medicinal product, as they may produce additive irritant effects.
Aklief should not come into contact with the eyes, eyelids, lips, or mucous membranes. If the product enter the eye, wash immediately and abundantly with lukewarm water.
Excessive exposure to sunlight, including sunlamps or phototherapy should be avoided during the treatment. An increased risk of sunburn was reported in 1.7% of the children, compared to 0.7% of the adults. Use of a broad-spectrum, water-resistant sunscreen with a Sun Protection Factor (SPF) of 30 or higher and protective clothing over treated areas is recommended when exposure cannot be avoided.
This product contains propylene glycol that may cause skin irritation.
Effects on laboratory tests: No data available.
Effects on Ability to Drive and Use Machines: The effects of trifarotene on a person's ability to drive and use machines were not assessed as part of its registration.
Use in Children: The safety of Aklief in children below 12 years old has not been established.
Use in the Elderly: No data available.