Aklief Drug Interactions

Effect of Aklief cream on other medicinal products: A clinical drug-drug interaction study has shown that topical application of trifarotene did not affect the circulating concentrations of hormonal contraceptives (ethinylestradiol and levonorgestrel) administered by oral route.
Effect of other medicinal products on Aklief cream: No clinical drug-drug interaction studies were performed to assess effects of other drugs on trifarotene systemic levels (see Pharmacology: Pharmacokinetics under Actions).
There is no data on the pharmacodynamic interaction potential of trifarotene. Caution should be exercised if cosmetics or acne medications with desquamative, irritant or drying effects are concomitantly used with the medicinal product, as they may produce additive irritant effects (see Precautions).
Pharmacokinetic drug interaction potential: In vitro studies show that Aklief cream at the concentrations achieved systemically after topical administration did not inhibit the CYP450 isoenzymes CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6 and 3A4, and did not induce CYP1A2, 2B6, or 3A4.
In vitro studies have shown that Aklief cream at the concentrations achieved systemically after topical administration did not inhibit either MATE, OATP, OAT or OCT uptake transporters or BCRP, PgP, BSEP or MRP efflux transporters.
Effect of Aklief cream on other medicinal products: A clinical drug-drug interaction study has shown that topical application of trifarotene did not affect the circulating concentrations of hormonal contraceptives (ethinylestradiol and levonorgestrel) administered by oral route.
Effect of other medicinal products on Aklief cream: No clinical drug-drug interaction studies were performed to assess effects of other drugs on trifarotene systemic levels (see Pharmacology: Pharmacokinetics under Actions).
There is no data on the pharmacodynamic interaction potential of trifarotene. Caution should be exercised if cosmetics or acne medications with desquamative, irritant or drying effects are concomitantly used with the medicinal product, as they may produce additive irritant effects (see Precautions).