Pariet Dosage/Direction for Use

Adults: Active Duodenal Ulcer and Active Benign Gastric Ulcer: Recommended Dose: 20 mg once daily in the morning. Some patients with active duodenal ulcer may respond to 10 mg once daily.
Most patients with active duodenal ulcer heal within 4 weeks. However, a few patients may require an additional 4 weeks of therapy to achieve healing. Most patients with active benign gastric ulcer heal within 6 weeks. However, again a few patients may require an additional 6 weeks of therapy to achieve healing.
Erosive or Ulcerative Gastroesophageal Reflux Disease (GERD): Recommended Dose: 20 mg once daily for 4-8 weeks.
Gastroesophageal Reflux Disease Long-Term Management (GERD Maintenance): 10 or 20 mg once daily depending upon patient response.
Symptomatic Treatment of Moderate to Very Severe Gastroesophageal Reflux Disease (Symptomatic GERD): 10 mg once daily in patients without esophagitis. If symptom control has not been achieved during 4 weeks, the patient should be further investigated.
Eradication of H. pylori: Patients with H. pylori infection should be treated with eradication therapy. The following combination given for 7 days is recommended: 20 mg twice daily + clarithromycin 500 mg twice daily and amoxicillin 1 g twice daily.
For indications requiring once-daily treatment, Pariet should be taken in the morning before eating, and although neither the time of day nor food intake was shown to have any effect on sodium rabeprazole activity, this regimen will facilitate treatment compliance.
Renal and Hepatic Impairment: No dosage adjustment is necessary for patients with renal or hepatic impairment. See precautions in the treatment of patients with severe hepatic impairment.