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The sedative effect of intravenous Midazolam is accentuated by any concomitantly administered medication, which depresses the central nervous system, particularly narcotics (e.g. Morphine, Meperidine and Fentanyl) and also Secobarbital and Droperidol.
With drugs that are known to inhibit the P450 3A4 enzyme system such as Cimetidine (not Ranitidine), Erythromycin, Diltiazem, Verapamil, Ketoconazole, and Itraconazole may result in prolonged sedation due to a decrease in plasma clearance of Midazolam.
Midazolam enhances the central sedative effect of neuroleptics, tranquilizers, antidepressants, sleep-inducing drugs, analgesics and anesthetics. This potentiation can be of advantage therapeutically.
