Midasan Dosage/Direction for Use

Standard dosage and mode of administration: In the case of elderly patients with organic cerebral changes or impaired cardiac and respiratory function, the dosage should be determined with caution, the special factors relating to each patient being taken into consideration.
i.v. injection must be given slowly (approximately 2.5 mg in 10 seconds for induction of anesthesia and 1 mg in 30 seconds for basal sedation). The drug takes effects about 2 minutes after the injection is started.
Premedication before an operation: i.m. administration: In patients suffering from pain before an intervention: Administration MIDASAN alone or in combination with anticholinergics and possibly analgesics. Usual doses about 5 mg.
Elderly and debilitated patients: 0.025-0.05 mg/Kg Body Weight i.m. These doses should be administered about 30 minutes before induction anesthesia.
Adult: 0.07-0.1 mg/Kg i.m. standard dosage about 5 mg, according to age and general condition of patients.
Induction of anesthesia and conscious sedation: i.v. administration: As an induction agent in inhalation of anesthesia and conscious sedation.
The dose is ±10 mg i.v.
A sufficiently deep level of sleep is generally achieved after 2-3 minutes. Dose should be reduced in elderly patients (above 55 years).
Maintenance of anesthesia: i.v. administration: For maintenance of desired level of unconsciousness, further small doses should be injected i.v. The dose and the intervals between doses vary according to the individual reaction of the patients. These additional doses should be given only after through clinical evaluation clearly indicates the need for additional sedation.
When MIDASAN is given with potent analgesics, the latter should be administered first so that sedative effects of MIDASAN can be safely titrated on top any sedation caused by analgesics.
Basal sedation: Intravenous basal sedation: For basal sedation in diagnostic or surgical carried out under local anesthesia: The initial dose is 2.5 mg 5-20 minutes before the beginning of the operation. Further dose 1 mg may be given as necessary. A total dose greater than 5 mg is not usually necessary to reach the desired end point.
In case of severe illness, particularly if the patient is in poor general condition or of advanced age, the initial dose must be reduced to 1-1.5 mg. Total doses greater than 3.5 mg are not usually necessary.