Conzace DV Drug Interactions

What other medicine or food should be avoided while taking this medicine: Vitamin A: Anticoagulant (e.g., warfarin): Concomitant administration with large doses of vitamin A may lead to increased risk of bleeding.
Retinoid (e.g., etretinate, isotretinoin, tretinoin): Avoid concomitant use of retinoids and preparations containing vitamin A or its derivatives because of the potential for additive side effects.
Minocycline: Concomitant administration may lead to increased risk of pseudomotor cerebri.
Statin: Prolonged statin treatment may increase serum vitamin A levels.
Vitamin C: Antacids: Concomitant use is not recommended specifically in patients with renal insufficiency since could increase the risk of aluminum toxicity.
Aspirin: Concomitant use may lead to increased urinary excretion of ascorbic acid and decreased excretion of aspirin.
Disulfiram: Prolonged administration of large doses of vitamin C (1 gram daily) may interfere with the alcohol-disulfiram reaction.
Fluphenazine: Concomitant administration with ascorbic acid resulted in decreased fluphenazine plasma level.
Mexiletine: Large doses of ascorbic acid (1 gram daily) of ascorbic acid may accelerate excretion of mexiletine.
Paracetamol: Ascorbic acid increases the apparent half-life of paracetamol.
Oral contraceptives (containing estrogen): These may reduce blood levels of ascorbic acid; large doses of vitamin C (>1 gram) may increase plasma estrogen levels; possibly breakthrough bleeding associated with withdrawal of high dose of vitamin C.
Warfarin: Ascorbic acid has reportedly decreased the anticoagulant effect of warfarin.
Others: Acidification of the urine following ascorbic acid administration may result in altered excretion of other drugs.
Vitamin E: Anticoagulant: Vitamin E reportedly may have anti-vitamin K effects; concomitant intake of anticoagulants (e.g., warfarin) and vitamin E may result in hemorrhage (bleeding).
Antiplatelets: High doses of vitamin E may also potentiate the effects of antiplatelets (e.g., aspirin, clopidogrel, ticlopidine) and herbs with anti-thrombotic activity such as garlic and ginkgo.
Zinc: Antibiotics (cephalosporins, quinolones, tetracyclines): Zinc decreases the absorption of these antibiotics. Taking the antibiotic at least 2 hours before or 4 to 6 hours after taking zinc supplement minimizes this interaction.
Bisphosphonate (alendronate, etidronate, risedronate): Concomitant intake of a bisphosphonate and zinc may decrease the absorption of both the bisphosphonate and zinc.
Cholesterol medicines: Additive effects are possible with concomitant administration. Use with caution.
Copper or iron: Concomitant administration with zinc inhibits the absorption of copper and iron. Administer zinc and copper or iron as far apart as possible.
Interference with Laboratory Test: Vitamin C interferes with the results of the following laboratory tests: Paracetamol, aspartate aminotransferase, bilirubin, carbamazepine, creatinine, glucose, lactate dehydrogenase, stool guaiac, theophylline and uric acid.