Avastor

Atorvastatin

Adjunct to diet for the reduction of total cholesterol (TC), LDL-C, apo B & triglycerides in patients w/ primary hypercholesterolemia, mixed hyperlipidemia, heterozygous familial hypercholesterolemia & HoFH when response to diet & other non-pharmacological management is inadequate. Prevention of CV complication in hypertensive patients ≥40 yr w/ dyslipidemia & at least 3 risk factors eg, LVH, ECG abnormalities, NIDDM, peripheral vascular disease, recent cerebrovascular disease including TIA, microalbuminuria/proteinuria, regular smoking, TC/HDL-C ratio ≥6, or a family history of CAD in a 1st-degree relative before 55 yr (male) or 60 yr (female). Adjunct to diet for the reduction of TC, LDL-C, & apo-B in boys & postmenarchal girls 10-17 yr w/ heterozygous familiar hypercholesterolemia, if LDL-C remains ≥190 mg/dL, or ≥160 mg/dL w/ family history of premature CV disease or ≥2 risk factors after adequate dietary intervention.

Initially 10 mg once daily. Dosage range: 10-80 mg once daily. Primary hypercholesterolemia & mixed hyperlipidemia 10 mg daily. HoFH 80 mg daily. Heterozygous familial hypercholesterolemia Childn 10-17 yr 10 mg daily. Max dose: 20 mg daily. Dose adjustment is made at intervals of ≥4 wk.

May be taken with or without food: Avoid excessive consumption (>1 L/day) of grapefruit juice.

Hypersensitivity. Active liver disease or persistent elevations of serum transaminases >3x ULN.

Discontinue therapy if there is a significant increase in CPK levels or if myopathy is suspected or diagnosed; in the presence of risk factor of secondary renal failure due to rhabdomylosis. Perform LFT before starting, 12 wk after, during dose evaluation, & regularly thereafter. Patients w/ diffuse myalgia, muscle pain or weakness, &/or significant increase in CPK; promptly report muscle pain, tenderness, or weakness especially if accompanied by malaise or fever.

Insomnia, headache, nausea, diarrhea, abdominal pain, dyspepsia, constipation, flatulence, myalgia, arthralgia, asthenia.

Concomitant use w/ CYP3A4 inhibitors, transporter inhibitors (cyclosporine), erythromycin/clarithromycin, PIs, diltiazem HCl, itraconazole, CYP3A4 inducers, antacids, colestipol, digoxin, azithromycin, OC containing norethindrone & ethinyl estradiol, colchicine, amlodipine, fusidic acid.

Dyslipidaemic Agents

C10AA05 - atorvastatin ; Belongs to the class of HMG CoA reductase inhibitors. Used in the treatment of hyperlipidemia.

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