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Click on icon to see table/diagram/imageAs Anastrozole lowers circulating oestrogen levels, it may cause a reduction in bone mineral density placing some patients at a higher risk of fracture (see Precautions).
Ischaemic cardiovascular events were reported more frequently in patients treated with Anastrozole compared to those treated with tamoxifen, although the difference was not statistically significant. The observed difference was mainly due to more reports of angina pectoris and was associated with a subgroup of patients with pre-existing ischaemic heart disease.
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