Zymoplex Special Precautions

Pharmacokinetic interaction between CYP2D6 inhibitors and tamoxifen has been reported in literature. This showed a reduction in plasma level of active tamoxifen metabolite, 4-hydroxy-N-desmethyltamoxifen. Reduced efficacy on tamoxifen has been reported with concomitant usage of some SSRI antidepressants (e.g. paroxetine).
In delayed breast reconstruction operation (weeks to years after the primary breast operation when the patient's own tissue is moved to shape a new breast) Zymoplex may increase the risk of the formation of blood clots in the small vessels of the tissue flap which may lead to complications.
Operations: If the patient is to undergo planned surgery, the patient must be advised to inform the doctor or pharmacist (as stopping the treatment for a short period may be considered).
Contraception: Women who can become pregnant should use adequate non-hormonal contraception (e.g., barrier contraception) during treatment with Zymoplex and for an additional two months after stopping treatment.
Driving and using machines: Zymoplex is not likely to affect the ability to drive or use any tools or machines. However, tiredness has been reported with the use of Zymoplex and caution should be observed when driving or operating machinery while such symptoms persist.
Use in Children: This medicine is not for use in children.