Zymoplex Side Effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.
Discontinue Zymoplex and advise the patient to seek medical advice straight away if any of the following side effects are present (urgent medical treatment may be needed): Symptoms of a blood clot. These include swelling of the calf or leg, chest pain, being short of breath or suddenly feeling weak; Symptoms of a stroke. These include sudden onset of the following: weakness or paralysis of the arms or legs, being unable to move the arms or legs, sudden difficulty with speaking, walking, difficulty in holding things or difficulty in thinking. These symptoms are caused by a reduced blood supply in the brain; Difficulty in breathing; Swelling of the face, lips, tongue or throat which may make it difficult to swallow; Swelling of the hands, feet or ankles; Nettle rash (also called 'hives' or 'urticaria').
Advise patient to seek medical advice in case of any of the following: Unusual bleeding from the vagina; Irregular periods, especially if associated with heavier bleeding as this could be a warning sign for a certain type of cancer affecting the lining of the womb (endometrial cancer); Vaginal discharge; A feeling of discomfort in the lower tummy (pelvis) such as pain or pressure. These effects may mean that there have been changes to the lining of the womb (the endometrium). Sometimes these effects are serious and could include cancer. They can happen during or after treatment with Zymoplex.
Other possible side effects: Very common (may affect more than 1 in 10 people): Nausea; Fluid retention; Skin rash; Hot flushes; Tiredness.
Common (may affect up to 1 in 10 people): Anaemia (a blood problem which means the patient has too few red blood cells); Changes in vision due to cataracts or changes to the retina of the eye; Increased amounts of fats in the blood (shown by blood tests); Allergic reactions; Leg cramp; Changes in the womb (including changes to its lining and benign growths); Headache; Feeling light-headed; Itching of the genitals; Thinning of the hair; Vomiting; Diarrhoea; Constipation; Changes in blood tests of liver function; Formation of fatty liver cells; Muscle pain; Sensory changes (including taste disorder and numbness or tingling in the skin); Increased risk of blood clots (including clots in small vessels).
Uncommon (may affect up to 1 in 100 people): Blood problems. This can make the patient bruise more easily, get serious infections, or feel very tired or breathless; Changes to the vision and difficulty seeing; Swelling of the pancreas. This may cause moderate to severe pain in the stomach; Changes in the amount of calcium in the blood. The signs may include feeling very sick, being sick a lot or being thirsty. Advise patients to inform the doctor if this happens (blood tests may be performed); Inflammation of the lungs. The symptoms may be like pneumonia (such as feeling short of breath and coughing); Liver cirrhosis (problems with the liver).
Rare (may affect up to 1 in 1,000 people): Severe blood problems. This can make the patient bruise more easily, get serious infections, or feel very tired or breathless; Changes to the cornea of the eye; Problems with the nerve that connects the retina to the brain; Swelling of the optic nerve; On occasion, more severe liver diseases have occurred from which some patients have died. These liver diseases include inflammation of the liver, liver cirrhosis, liver cell damage, reduced bile formation, and failure of the liver. Symptoms may include a general feeling of being unwell, with or without jaundice (yellowing of the skin and eyes); A severe rash with blisters or peeling of the skin and possibly blisters in the mouth and nose (Stevens-Johnson syndrome); Damage to blood vessels causing red or purple dots in the skin; Severe skin disorder. The symptoms include redness, blistering and peeling; Cells normally only found in the lining of the womb found elsewhere in the body, cysts on the ovaries, and cancer (the signs of this are given previously); Non-cancerous mass in the inner lining of the vagina (called vaginal polyp); At the beginning of treatment, a worsening of the symptoms of the breast cancer such as an increase in pain and/or an increase in the size of the affected tissue may occur (known as tumour flare).
Very rare (may affect up to 1 in 10,000 people): Inflammation of the skin characterized by rash or erythema, very often on areas exposed to light (a condition called cutaneous lupus erythematosus); A skin condition characterised by skin blisters in areas exposed to the light, this is due to the increased liver production of a special group of cell pigments (called porphyrins); Radiation recall - skin rash involving redness, swelling, and/or blistering (like severe sunburn) of the skin after receiving radiation therapy.
Reporting of side effects: Patients must be advised in case of any side effects. This includes any possible side effects not listed in this monograph. Reporting side-effects can help provide more information on the safety of this medicine.