Zadaxin Indications/Uses

Chronic Hepatitis B: Zadaxin is indicated for the treatment of chronic hepatitis B in patients with compensated liver disease and hepatitis B virus (HBV) replication (serum HBV DNA positive). Studies in patients who have been serum hepatitis B surface antigen (HBsAg) positive for at least 6 months with elevated serum alanine aminotransferase (ALT) demonstrate that treatment with Zadaxin therapy can produce virological remission (loss of serum HBV DNA) and normalization of serum aminotransferases. Zadaxin therapy resulted in the loss of serum HBsAg in some responding patients. Clinical trials have suggested that giving Zadaxin in combination with interferon α may increase the response rate over that seen with therapy using only Zadaxin or interferon α.
Vaccine Adjuvant: Zadaxin thymosin α₁ (thymalfasin) is indicated as an adjuvant (immune response enhancer) for influenza vaccination in immunocompromised patients. Thymosin α₁ is indicated as an adjuvant for influenza vaccine in elderly patients as an adjuvant for both influenza and hepatitis B vaccines in chronic hemodialysis patients who failed to achieve adequate antibody titers from previous immunization. See Table 1.
Click on icon to see table/diagram/image