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Each vial of Zadaxin also contains the following excipients: Mannitol 50 mg and sodium phosphate buffer to adjust the pH to 6.8.
Prior to administration, the lyophilized powder is to be reconstituted with 1 mL of the provided diluent (sterile water for injection). After reconstitution, the final concentration of Zadaxin is 1.6 mg/mL.
Zadaxin for SC injection is a purified, sterile, lyophilized preparation of chemically synthesized thymosin α1 identical to human thymosin α1.
Thymosin α1 is an acetylated polypeptide with the following sequence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH. It has a molecular weight of 3108 daltons.
Thymosin α1 is also known as thymalfasin.
