Excipients/Inactive Ingredients: Sodium Chloride, Acetic Acid, Sodium Acetate and Water for Injection.
Addisonian pernicious anaemia. Prophylaxis and treatment of other macrocytic anaemias associated with Vitamin B-12 deficiency. Schilling test.
The following dosage schemes are suitable for adults and children.
Addisonian pernicious anaemia and other macrocytic anaemias without neurological involvement: Initially: 250 to 1,000 micrograms intramuscularly on alternate days for one or two weeks, then 250 micrograms weekly until the blood count is normal.
Maintenance: 1,000 micrograms monthly.
Addisonian pernicious anaemia and other macrocytic anaemias, anaemias with neurological complications: Initially: 1,000 micrograms intramuscularly on alternate days as long as improvement is occurring.
Prophylaxis of macrocytic anaemia associated with Vitamin B-12 deficiency resulting from gastroectomy, some malabsorption syndromes and strict vegetarism: 250 to 1,000 micrograms monthly.
Schilling test: An intramuscular injection of 1,000 micrograms cyanocobalamin is an essential part of this test.
Treatment is unlikely to be needed in cases of overdosage.
Hypersensitivity to cyanocobalamin.
Not indicated for treatment of toxic amblyopias.
The dosage schemes given are usually satisfactory, but regular examination of the blood is advisable. If megaloblastic anaemia fails to respond to Cyanocobalamin Injection, folate metabolism should be investigated.
Doses in excess of 10 micrograms daily may produce a haematological response in patients with folate deficiency.
Indiscriminate administration may mask the true diagnosis. Cardiac arrhythmias secondary to hypokalaemia during initial therapy have been reported. Plasma potassium should therefore be monitored during this period.
Vitamin B-12 Injection should not be used for the treatment of megaloblastic anaemia of pregnancy.
Sensitisation of cyanocobalamin is rare but it may present as an itching exanthema, chills, fever, hot flushes, nausea, and dizziness, and exceptionally as anaphylactic shock. Acneiform and bullous eruptions have been reported rarely.
Chloramphenicol-treated patients may respond poorly to Vitamin B-12 Injection. Serum concentrations of cyanocobalamin may be lowered by oral contraceptives. These interactions are unlikely to have clinical significance. Antimetabolites and most antibiotics invalidate Vitamin B-12 assays by microbiological techniques.
Store below 25°C. Protect from light.
B03BA01 - cyanocobalamin ; Belongs to the class of vitamin B12 (cyanocobalamin and analogues). Used in the treatment of anemia.
Vitamin B12 Inj - Panpharma soln for inj 1,000 mcg/mL
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