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The following dosage schemes are suitable for adults and children.
Addisonian pernicious anaemia and other macrocytic anaemias without neurological involvement: Initially: 250 to 1,000 micrograms intramuscularly on alternate days for one or two weeks, then 250 micrograms weekly until the blood count is normal.
Maintenance: 1,000 micrograms monthly.
Addisonian pernicious anaemia and other macrocytic anaemias, anaemias with neurological complications: Initially: 1,000 micrograms intramuscularly on alternate days as long as improvement is occurring.
Prophylaxis of macrocytic anaemia associated with Vitamin B-12 deficiency resulting from gastroectomy, some malabsorption syndromes and strict vegetarism: 250 to 1,000 micrograms monthly.
Schilling test: An intramuscular injection of 1,000 micrograms cyanocobalamin is an essential part of this test.
