MMR II Drug Interactions

Corticosteroids and Immunosuppressive Drugs: M-M-R II vaccine should not be administered to individuals receiving immunosuppressive therapy, including high dose corticosteroids. Vaccination with M-M-R II vaccine can result in disseminated disease due to measles vaccine in individuals on immunosuppressive drugs [see Immunosuppression under Contraindications].
Immune Globulins and Transfusions: Administration of immune globulins and other blood products concurrently with M-M-R II vaccine may interfere with the expected immune response [see Immune Globulins and Transfusions under Precautions]. The ACIP has specific recommendations for intervals between administration of antibody containing products and live virus vaccines.
Tuberculin Skin Testing: It has been reported that live attenuated measles, mumps and rubella virus vaccines given individually may result in a temporary depression of tuberculin skin sensitivity. Therefore, if a tuberculin skin test with tuberculin purified protein derivative (PPD) is to be done, it should be administered before, simultaneously with, or at least 4 to 6 weeks after vaccination with M-M-R II vaccine.
Use with Other Live Viral Vaccines: M-M-R II vaccine can be administered concurrently with other live viral vaccines. If not given concurrently, M-M-R II vaccine should be given one month before or one month after administration of other live viral vaccines to avoid potential for immune interference.