MMR II Dosage/Direction for Use

For subcutaneous use only.
Dose and Schedule: Each 0.5 mL dose is administered subcutaneously.
The first dose is administered at 12 to 15 months of age. A second dose is administered at 4 to 6 years of age.
The second dose may be administered prior to 4 years of age, provided that there is a minimum interval of one month between the doses of measles, mumps and rubella virus vaccine, live.
Children who received an initial dose of measles, mumps and rubella vaccine prior to their first birthday should receive additional doses of vaccine at 12-15 months of age and at 4-6 years of age to complete the vaccination series [see Pharmacology: Clinical Studies: Immunogenicity under Actions].
For post-exposure prophylaxis for measles, administer a dose of M-M-R II vaccine within 72 hours after exposure.
Preparation and Administration: Use a sterile syringe free of preservatives, antiseptics, and detergents for each injection and/or reconstitution of the vaccine because these substances may inactivate the live virus vaccine. To reconstitute, use only the diluent supplied with the vaccine since it is free of preservatives or other antiviral substances which might inactivate the vaccine.
PREFILLED SYRINGE OF DILUENT: To reconstitute the vaccine, inject the entire content of the syringe into the vial of lyophilized vaccine and gently agitate to mix thoroughly. Withdraw the entire contents of the reconstituted vaccine vial into the same syringe and inject the entire volume.
If two needles are provided: use one needle to reconstitute the vaccine and the other for its administration to the person to be vaccinated.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Visually inspect the vaccine before and after reconstitution prior to administration. Before reconstitution, the lyophilized vaccine is a light yellow compact crystalline plug, when reconstituted, is a clear yellow liquid. Discard if particulate matter or discoloration are observed in the reconstituted vaccine.
To minimize loss of potency, administer M-M-R II as soon as possible after reconstitution. If not used immediately, the reconstituted vaccine may be stored between 36°F to 46°F (2°C to 8°C), protected from light, for up to 8 hours. Discard reconstituted vaccine if it is not used within 8 hours.