Lastet Special Precautions

General Precautions: As serious adverse drug reactions such as bone marrow depression may occur, patients should be monitored closely by frequent laboratory examinations (hematology, hepatic and renal function). If any abnormality is observed, appropriate measures should be taken such as reducing dosage or cessation of administration. Long term administration should be carried out with great caution because of its potentiality of causing severer and intractable adverse drug reactions.
Particular attention should be paid to the manifestation or aggravation of both infection and bleeding tendency.
Administration to children should be carried out with great caution paying attention to manifestation of adverse drug reactions.
Particular effects on the sexual gland should be considered when this drug is necessary to administer to children or patients at an age capable of reproductive potential.
Careful Administration: This product should be administered with caution in the followings: Patients with bone marrow depression, patients with hepatic disorders, patients with renal disorders, patients with infection, Varicella patients (fatal systemic reaction may occur).
Other: The occurrence of acute leukemia (in some cases accompanied with a preleukemic phase) has been reported in patients treated with Etoposide in combination with other antineoplastic agents.
Use in the Elderly: Since the elderly often have a physiological hypofunction (hematopoietic dysfunction, hepatic function disorder, renal function disorder, etc.), administration should be done with a care for the dosage and administration interval under careful observation of the patient's condition.