Lastet Description

Each capsule contains 50 mg of etoposide in capsule.
Etoposide is an antitumor agent that was chemically synthesized in 1966 from podophyllotoxin. Pharmacologically, it possesses cytocidal activity acting at the late S phase and G₂ phase of the cell cycle and demonstrates blocking of the G₂ phase. It is thought that its mechanism of action involves inducing scission of the DNA chain without directly acting on it.
Clinically, it has been recognized effective against small cell lung cancer, malignant lymphomas and other similar disorders.
The content of all of the capsules is a colorless to light yellow, clear, viscous liquid.
Chemical name: (-)-(5R,5aR,8aR,9S)-9-[[4,6-O-(R)-eth-ylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo [3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one.
Molecular formula: C₂₉H₃₂O₁₃.
Molecular weight: 588.57.
Etoposide is a white crystal or white crystalline powder. It is sparingly soluble in methanol or chloroform, slightly soluble in ethanol and very slightly soluble in water or ethylether.
Melting point: approx. 260°C (decomposition).
I.D. No: NK 7012.
Length: 17.4 mm.
Cross-Section: 8.8 mm.
Weight: 1.02 g.
Excipients/Inactive Ingredients: polyethylene glycol, ethyl paraben, propyl paraben.