Symptoms and treatment: Overdosage has not been known to occur during topical therapy with Fusidic Acid or Sodium Fusidate. Corticosteroid applied to the skin can be absorbed in sufficient amount to produce systemic effect, such as hypothalamic-pituitary-adrenal axis suppression, manifestation of Cushing's Syndrome, hyperglycaemia and glucosuria. If hypothalamic-pituitary-adrenal axis suppression is found, then the drug should be withdrawn, frequency of application reduced or a weaker steroid used. Supplemental systemic corticosteroids may be required it signs and symptoms of steroid withdrawal occur.
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